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AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.
来源:杭州师范大学生命科学研究院 作者:杨爱芬 时间:2018-06-15 15:19:43 阅读:<span id="hitcount2056329">97</span><script src="https://search.hznu.edu.cn/zcms/counter?Type=Article&ID=2056329&DomID=hitcount2056329"></script>

AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination.

Jiang C, Yang W, Fan Z, Teng P, Mei R, Yang J, Yang A, Qiu M, Zhao X.

Neurosci Bull. 2018 Jun;34(3):527-533. doi: 10.1007/s12264-018-0218-6. Epub 2018 Mar 19.


Abstract

Oligodendrocytes (OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYK-deficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.


全文链接:https://dx.doi.org/10.1007/s12264-018-0218-6



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