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杜立群课题组
来源:生研院 作者:admin 时间:2016-12-12 14:14:19 阅读:<span id="hitcount885236">1536</span><script src="https://search.hznu.edu.cn/zcms/counter?Type=Article&ID=885236&DomID=hitcount885236"></script>

杜立群

Phone, 0571-28865199

E-mail, liqundu@hznu.edu.cn

地址:浙江省下沙高教园区学林街16号,杭州,310036

主要研究方向为植物分子生物学。从事植物信号转导分子机理方面的研究,侧重植物细胞钙信号转导、植物逆境胁迫下钙调素的调控作用等,并在植物科学领域取得过突破性进展。在生命科学领域高级学术期刊上发表论文20余篇,其中《Nature》2篇,并在Journal of Biological Chemistry和Plant Molecular Biology等多种杂志上发表论文多篇。多次获得美国资助项目。2013年浙江省高等学校“钱江学者”,2011年获得国家自然科学基金联合基金项目。

在分析解剖钙调蛋白介导的钙信号解读方面,取得过突破性的进展。在植物生物技术、生物化学、分子生物学方面有丰富的研究经验,擅长各种研究蛋白相互作用的技术,包括在酵母、植物细胞中研究蛋白质相互作用的技术,以及各类蛋白共沉降技术。熟练掌握了各类常规的细胞学、遗传学分析技术。了解并熟练掌握现代新兴的高通量基因组、蛋白组、突变体的遗传筛选等技术。

教育经历

1983-1987,中山大学,生物系植物学专业,本科

1987-1990,中国科学院遗传研究所,遗传学专业,硕士

1996-1999,中国科学院植物研究所,植物学专业,博士

工作经历

1999-2002,美国爱达荷大学,访问学者

2002-2007,美国华盛顿州立大学,博士后

2007-2011,美国华盛顿州立大学,助理教授(Research Assistant Professor)

2011,美国华盛顿州立大学,副教授(Research Associate Professor)

2011-至今,杭州师范大学,生命与环境科学学院,教授

科研项目

1.干旱感受器基因在新疆极端干旱环境下植物生态适应机制中的作用及抗旱基因资源的开发资助(U1130304),NSFC-新疆联合基金重点项目,2012-2015,主持,172万

2.Calcium/Calmodulin-mediated Signaling during Plant-microbe Interactions,美国国家自然科学基金会,共同主持,0,000

3.Biologically Intensive Organic Farming Approach Utilizing Natural Symbiotic Association between Plants and Microbes, 华盛顿州生物农业项目,2010-2012, 共同主持,,000

4.杂交捕获及释放技术分离黑麦、偃麦草基因组特异DNA片段(KZ95T-02-02-12),中国科学院特支项目,1997-2000,主持,15万

5.杂交捕获及释放技术鉴定小黑麦易位系(KY951-A1-302),中国科学院重大项目,1997-2000,主持,20万

主要成绩

2013年浙江省高等学校“钱江学者”,美国植物学家学会和美国科学促进会会员,2007年和2010年在美国授权获得两项重要专利

专利

1. Size and/or Growth Engineering by Modulation of the Interaction between Calmodulin, and Brassinosteroid Biosynthetic Enzymes and Orthologs thereof,United States Patent Application,Patent Number 20070089183,2007.04,杜立群(A1)

2. COMPOSITIONS AND METHODS FOR MODULATING PLANT DISEASE RESISTANCE AND IMMUNITY,United States Patent Application,Patent Number US2010/0223690,2010.02杜立群(A1)

2.

论文专著

1. Guoping Wang,Houqing Zeng,Xiaoyan Hu,Yiyong Zhu,Yang Chen,Chenjia Shen,Huizhong Wang,B. W.Poovaiah,Liqun Du(*),Identification and expression analyses of calmodulin-binding transcription activator genes in soybean,Plant and Soil386,205-221 (2014)

2. Pi, Erxu,Mantri, Nitin,Ngai, Sai Ming,Lu, Hongfei(*),Du, Liqun(*),BP-ANN for fitting the temperature-germination model and its application in predicting sowing time and region for Bermudagrass. PLos One8,12(2013)

3. Lei zhang,Liqun Du,B. W. Poovaiah(*),CytoTrap Two-Hybrid Screening Assay,Bio-protocol,4,(23)(2014)

4. Zhang, Lei(#),Du, Liqun,Poovaiah, B W,Calcium signaling and biotic defense responses in plants.,Plant Signal Behav,9(11), (2014)

5. Zhang, Lei,Du, Liqun,Shen, Chenjia,Yang, Yanjun,Poovaiah, B. W.(*) Regulation of plant immunity through ubiquitin-mediated modulation of Ca(2+) -calmodulin-AtSR1/CAMTA3 signaling.,Plant Journal,78(2),269-281(2014)

6. Qiu, Yongjian(#),Xi, Jing,Du, Liqun,Poovaiah, B W,The function of calreticulin in plant immunity, new discoveries for an old protein.,Plant Signal Behav, 7(8):907-910(2012)

7. Qiu, Yongjian(#),Xi, Jing,Du, Liqun,Suttle, Jeffrey C,Poovaiah, B W,Coupling calcium/calmodulin-mediated signaling and herbivore- induced plant response through calmodulin-binding transcription factor AtSR1/CAMTA3.,Plant Molecular Biology,79(1-2):89-99(2012)

8. Xi, Jing,Qiu, Yongjian,Du, Liqun,Poovaiah, B. W.(*),Plant-specific trihelix transcription factor AtGT2L interacts with calcium/calmodulin and responds to cold and salt stresses.,Plant Science,185-186:274-280(2012)

9. Routray, Pratyush,Miller, J Benjamin,Du, Liqun,Oldroyd, Giles,Poovaiah, B W,Phosphorylation of S344 in the calmodulin-binding domain negatively affects CCaMK function during bacterial and fungal symbioses.,Plant Journal, 76(2) 287-296(2013)

10. Poovaiah, B W,Du, Liqun,Wang, Huizhong,Yang, Tianbao,Recent advances in calcium/calmodulin-mediated signaling with an emphasis on plant-microbe interactions.,Plant Physiology,163(2):531-542(2013)

11. Qiu, Y., Xi, J., Du, L. and Poovaiah, B.W. The Function of Calreticulin in Plant Innate Immunity, New Discoveries for an Old Protein. Plant Signaling & Behavior 7, 907 – 910 (2012)

12. Qiu, Y., Xi, J., Du, L. and Poovaiah, B.W. Coupling calcium/calmodulin- mediated signaling and herbivore-induced plant response through calmodulin-binding transcription factor AtSR1/CAMTA3. Plant Molecular Biology 79, 89-99 (2012)

13. Xi, J., Qiu, Y., Du, L., Poovaiah, B. W. Plant-specific trihelix transcription factor AtGT2L interacts with calcium/calmodulin and responds to cold and salt stresses. Plant Science 185–186, 274-280 (2012).

14. Qiu, Y., Xi, J., Du, L., Roje, S. & Poovaiah, B.W. A dual regulatory role of Arabidopsis calreticulin-2 in plant innate immunity. The Plant Journal 69, 489-500 (2012).

15. Yang, T., Ali, G. S., Yang, L., Du, L., Reddy, A. S., Poovaiah, B. W. Calcium/calmodulin-regulated receptor-like kinase CRLK1 interacts with MEKK1 in plants. Plant Signaling & Behavior 5, 991-994 (2010)

16. Yang, T., Chaudhuri, S., Yang, L., Du, L. & Poovaiah, B.W. A Calcium/Calmodulin-regulated Member of the Receptor-like Kinase Family Confers Cold Tolerance in Plants. Journal of Biological Chemistry 285, 7119-7126 (2010)

17. Du, L., Ali, G. S., Simons, K. A., Hou, J., Yang, T., Reddy, A.S.N. and Poovaiah, B. W. Ca2+/calmodulin Regulates Salicylic Acid-mediated Plant Immunity. Nature 457, 1154-1158 (2009).

18. Yang, T., Du, L*. and Poovaiah, B. W. Concept of redesigning proteins by manipulating calcium/calmodulin-binding domains to engineer plants with altered traits. Functional Plant Biology 34, 343-352 (2007). (*Co-Primary author)

19. Du, L. and Poovaiah, B. W. Ca2+/Calmodulin is critical for brassinosteroid biosynthesis and plant growth. Nature 437, 741-745 (2005).

20. Du, L. and Poovaiah, B. W. A Novel Family of Ca2+/Calmodulin-binding Proteins Involved in Transcriptional Regulation, Interaction With fsh/Ring3 Class Transcription Activators. Plant Molecular Biology 54, 549-569 (2004).

21. Chen, K., Fan, B., Du, L. and Chen, Z. Activation of hypersensitive cell death by pathogen-induced receptor-like protein kinases from Arabidopsis. Plant Molecular Biology 56, 271-283 (2004).

22. Chen, K., Du, L., Chen, Z. Sensitization of defense responses and activation of programmed cell death by a pathogen-induced receptor-like protein kinase in Arabidopsis. Plant Molecular Biology 53, 61-74 (2003).

23. Du, L. and Chen, Z. Identification of Genes encoding receptor-like protein kinase as possible targets of pathogen- and salicylic acid- induced WRKY DNA-binding proteins in Arabidopsis. The Plant Journal 24, 837-847 (2000).

24. Li, H., Guo, B., Zhang, Y., Li, Y., Du, L., Li, Y., Jia, X., Zhu, Z. High efficient intergeneric Chromosomal Translocation between Wheat (Triticum aestivum) and Dasypyrum villosum arising from tissue culture and Irradiation. Acta Genetica Sinica 27, 511-519 (2000).

25. Guo, B., Zhang, Y., Li, H., Du, L. et al. Transformation of Wheat with a Gene Encoding for the Betain-aldehyde Dehydrogenase (BADH). Acta Botanica Sinica 42, 279-283 (2000).

26. Li, Y., Chang, F., Du, L., Li, H. et al. Genetic Transformation of Watercress with a Gene Enoding for Betain-aldehyde Dehydrogenase (BADH). Acta Botanica Sinica 42, 480-484 (2000).

27. Guo, B., Zhang, Y., Li, H., Wang, Z., Zhang, Z., Li, S., Wang, B., Du, L., Li, Y., Zhu, Z. Detection of a RAPD Marker Linked to rht Gene in Wheat (Triticum aestivum L. ). Acta Agronomica Sinica 26, 420-423 (2000).

28. Li, H., Guo, B., Li, Y., Du, L., Jia, X., Chu, C. C. Molecular Cytogenetic analysis of intergeric chromosomal translocations between wheat (Triticum aestivum) and Dasypyrum villosum arising from tissue culture. Genome 43, 756-762 (2000).

29. Du, L., Li, Y., Li, H., et al. Screening of Salt Tolerant Watercress Variants On media Containing 1/3 Natural Seawater. Acta Botanica Sinica 41, 633-639 (1999).

30. Li, H., Zhu, Z., Du, L., Guo, B., et al. Detection of Alien Chromatins Introgressed into Wheat in Mitotic Interphase. Acta Genetica Sinica 26, 666-672 (1999).

31. Zhang, Z., Du, L., Li, Y. et al. The Variations of M1 to the Seeds of Tobacco Implanted with Ion Beam, Acta Biophysica Sinica 14, 762-766 (1999).

32. Du, L., Li, Y., Ma, M., et al Preliminary Study on Transformation of Wheat Apical Point, Acta Botanica Sinica 38, 921-924 (1996).

33. Du, L., Wang, H., Huang, F. et al. Genetic Transformation of Lycium barbarum L. via A. tumefaciens,Science in China(Series B) 37, 286-292 (1994).

34. He, S., Lu, S., Du, L., Li, Y. et al. Plant Regeneration from rhizome of Hybrid of C. goeringii and C.sinense, Chinese Bulletin of Botany 11 (suppl.), 58-59 (1994).

35. Wang, H., Du, L., Deng, W. et al. Study on the Transformation of Three Species of Economic Plants, Genetic Manipulation in Plants 7, 101-105 (1992).

36. Wang, H., Du, L., Shao, Q. et al. Somatic Embryogenesis and Plant Regeneration from Immature Embryo Tissue of Soybean, Genetic Manipulation in Plants 6, 52-58 (1990).



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